Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors. Deletion or inhibition of the TRPM8 channel was found to prevent th...

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Vydáno v:Mol Brain
Hlavní autoři: Iftinca, Mircea, Basso, Lilian, Flynn, Robyn, Kwok, Charlie, Roland, Corinne, Hassan, Ahmed, Defaye, Manon, Ramachandran, Rithwik, Trang, Tuan, Altier, Christophe
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155267/
https://ncbi.nlm.nih.gov/pubmed/32290846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-020-00599-0
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