Differential Role of Serines and Threonines in Intracellular Loop 3 and C-Terminal Tail of the Histamine H(4) Receptor in β-Arrestin and G Protein-Coupled Receptor Kinase Interaction, Internalization, and Signaling

[Image: see text] The histamine H(4) receptor (H(4)R) activates Gα(i)-mediated signaling and recruits β-arrestin2 upon stimulation with histamine. β-Arrestins play a regulatory role in G protein-coupled receptor (GPCR) signaling by interacting with phosphorylated serine and threonine residues in the...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Verweij, Eléonore W. E., Al Araaj, Betty, Prabhata, Wimzy R., Prihandoko, Rudi, Nijmeijer, Saskia, Tobin, Andrew B., Leurs, Rob, Vischer, Henry F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155198/
https://ncbi.nlm.nih.gov/pubmed/32296771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00008
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