Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds

[Image: see text] Cannabinoid receptor 1 (CB(1)) is a key drug target for a number of diseases, including metabolic syndromes and neuropathic pain. Most of the typical cannabinoid ligands provoke psychotropic side effects that impair their therapeutic utility. As of today, it is not yet clearly know...

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Veröffentlicht in:ACS Pharmacol Transl Sci
Hauptverfasser: Wouters, Elise, Walraed, Jolien, Robertson, Michael Joseph, Meyrath, Max, Szpakowska, Martyna, Chevigné, Andy, Skiniotis, Georgios, Stove, Christophe
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155187/
https://ncbi.nlm.nih.gov/pubmed/32296768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00069
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