Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S‐Equol and Its Consequences for ERα Activation

SCOPE: To predict gut microbial metabolism of xenobiotics and the resulting plasma concentrations of metabolites formed, an in vitro–in silico‐based testing strategy is developed using the isoflavone daidzein and its gut microbial metabolite S‐equol as model compounds. METHODS AND RESULTS: Anaerobic...

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Detalhes bibliográficos
Publicado no:Mol Nutr Food Res
Main Authors: Wang, Qianrui, Spenkelink, Bert, Boonpawa, Rungnapa, Rietjens, Ivonne M. C. M., Beekmann, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154660/
https://ncbi.nlm.nih.gov/pubmed/32027771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201900912
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