Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation

BACKGROUND: Although aortic regurgitation (AR) is a clinically important condition that is becoming increasingly common, few relevant murine models and mechanistic studies exist for this condition. In this study, we attempted to delineate the pathological and molecular changes and address the roles...

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Dades bibliogràfiques
Publicat a:Ann Transl Med
Autors principals: Wu, Jian, You, Jieyun, Wang, Xiaoyan, Wang, Shijun, Huang, Jiayuan, Xie, Qihai, Gong, Baoyong, Ding, Zhiwen, Ye, Yong, Wang, Cong, Kang, Le, Xu, Ran, Li, Yang, Chen, Ruizhen, Sun, Aijun, Yang, Xiangdong, Jiang, Hong, Yang, Fenghua, Backx, Peter H., Ge, Junbo, Zou, Yunzeng
Format: Artigo
Idioma:Inglês
Publicat: AME Publishing Company 2020
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154424/
https://ncbi.nlm.nih.gov/pubmed/32309366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2020.01.51
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