Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation

BACKGROUND: Although aortic regurgitation (AR) is a clinically important condition that is becoming increasingly common, few relevant murine models and mechanistic studies exist for this condition. In this study, we attempted to delineate the pathological and molecular changes and address the roles...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Wu, Jian, You, Jieyun, Wang, Xiaoyan, Wang, Shijun, Huang, Jiayuan, Xie, Qihai, Gong, Baoyong, Ding, Zhiwen, Ye, Yong, Wang, Cong, Kang, Le, Xu, Ran, Li, Yang, Chen, Ruizhen, Sun, Aijun, Yang, Xiangdong, Jiang, Hong, Yang, Fenghua, Backx, Peter H., Ge, Junbo, Zou, Yunzeng
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154424/
https://ncbi.nlm.nih.gov/pubmed/32309366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2020.01.51
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