Deposition of Centromeric Histone H3 Variant CENP-A/Cse4 into Chromatin Is Facilitated by Its C-Terminal Sumoylation

Centromeric localization of CENP-A (Cse4 in Saccharomyces cerevisiae, CID in flies, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of overexpressed CENP-A contributes to aneuploidy in yeast, flies, and humans, and is proposed to promote tumorigenesis in human can...

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Veröffentlicht in:Genetics
Hauptverfasser: Ohkuni, Kentaro, Suva, Evelyn, Au, Wei-Chun, Walker, Robert L., Levy-Myers, Reuben, Meltzer, Paul S., Baker, Richard E., Basrai, Munira A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Genetics Society of America 2020
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Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153950/
https://ncbi.nlm.nih.gov/pubmed/32111629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303090
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