Contribution of Rare Variants of the SLC22A12 Gene to the Missing Heritability of Serum Urate Levels

Gout is a common arthritis caused by monosodium urate crystals. The heritability of serum urate levels is estimated to be 30–70%; however, common genetic variants account for only 7.9% of the variance in serum urate levels. This discrepancy is an example of “missing heritability.” The “missing herit...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Misawa, Kazuharu, Hasegawa, Takanori, Mishima, Eikan, Jutabha, Promsuk, Ouchi, Motoshi, Kojima, Kaname, Kawai, Yosuke, Matsuo, Masafumi, Anzai, Naohiko, Nagasaki, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2020
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153932/
https://ncbi.nlm.nih.gov/pubmed/32005656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.303006
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