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Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody
Selecting the dose for efficacy and first-in-human studies of bispecific antibodies (BsAbs) is a challenging process. Herein, positron emission tomography (PET) imaging with (89)Zr-labeled IBI322, an anti-CD47/PD-L1 BsAb, was used to optimize the safety and effective therapy dose. By labeling with (...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | MAbs |
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Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Taylor & Francis
2020
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7153848/ https://ncbi.nlm.nih.gov/pubmed/32275842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1748322 |
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