Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors

Mesothelin (MSLN) is a cell surface glycoprotein overexpressed in several solid malignancies, including gastric, lung, mesothelioma, pancreatic and ovarian cancers. While several MSLN-targeting therapeutic approaches are in development, only limited efficacy has been achieved in patients. A potentia...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:MAbs
Autori principali: Hatterer, Eric, Chauchet, Xavier, Richard, Françoise, Barba, Leticia, Moine, Valéry, Chatel, Laurence, Broyer, Lucile, Pontini, Guillemette, Bautzova, Tereza, Juan, Flora, Calloud, Sebastien, Bosson, Nicolas, Charreton, Maud, Masternak, Krzysztof, Buatois, Vanessa, Shang, Limin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153835/
https://ncbi.nlm.nih.gov/pubmed/32191151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1739408
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi