Identification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibody

T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint that regulates normal immune responses but can be exploited by tumor cells to evade immune surveillance. TIM-3 is primarily expressed on immune cells, particularly on dysfunctional and exhausted T cells, and engagement of TIM-3...

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Bibliografische gegevens
Gepubliceerd in:Oncoimmunology
Hoofdauteurs: Zhang, Dong, Jiang, Feng, Zaynagetdinov, Rinat, Huang, Hui, Sood, Vanita D., Wang, Hong, Zhao, Xinyan, Jenkins, Molly H., Ji, Qingyong, Wang, Youbin, Nannemann, David P., Musil, Djordje, Wesolowski, John, Paoletti, Andrea, Bartholomew, Tin, Derner, Melissa G., An, Qi, Iffland, Christel, Halle, Joern-Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2020
Onderwerpen:
Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153820/
https://ncbi.nlm.nih.gov/pubmed/32313722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1744921
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