Identification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibody

T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint that regulates normal immune responses but can be exploited by tumor cells to evade immune surveillance. TIM-3 is primarily expressed on immune cells, particularly on dysfunctional and exhausted T cells, and engagement of TIM-3...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Zhang, Dong, Jiang, Feng, Zaynagetdinov, Rinat, Huang, Hui, Sood, Vanita D., Wang, Hong, Zhao, Xinyan, Jenkins, Molly H., Ji, Qingyong, Wang, Youbin, Nannemann, David P., Musil, Djordje, Wesolowski, John, Paoletti, Andrea, Bartholomew, Tin, Derner, Melissa G., An, Qi, Iffland, Christel, Halle, Joern-Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153820/
https://ncbi.nlm.nih.gov/pubmed/32313722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1744921
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