Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy

[Image: see text] The action of arginase, a metalloenzyme responsible for the hydrolysis of arginine to urea and ornithine, is hypothesized to suppress immune-cell activity within the tumor microenvironment, and thus its inhibition may constitute a means by which to potentiate the efficacy of immuno...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Med Chem Lett
मुख्य लेखकों: Mitcheltree, Matthew J., Li, Derun, Achab, Abdelghani, Beard, Adam, Chakravarthy, Kalyan, Cheng, Mangeng, Cho, Hyelim, Eangoor, Padmanabhan, Fan, Peter, Gathiaka, Symon, Kim, Hai-Young, Lesburg, Charles A., Lyons, Thomas W., Martinot, Theodore A., Miller, J. Richard, McMinn, Spencer, O’Neil, Jennifer, Palani, Anandan, Palte, Rachel L., Saurí, Josep, Sloman, David L., Zhang, Hongjun, Cumming, Jared N., Fischer, Christian
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2020
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153280/
https://ncbi.nlm.nih.gov/pubmed/32292567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00058
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन