An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease

Oligomers of β-amyloid 42 (Aβ42), rather than fibrils, drive the pathogenesis of Alzheimer's disease (AD). In particular, toxic oligomeric species called protofibrils (PFs) have attracted significant attention. Herein, we report RNA aptamers with higher affinity toward PFs derived from a toxic...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Murakami, Kazuma, Obata, Yayoi, Sekikawa, Asa, Ueda, Haruka, Izuo, Naotaka, Awano, Tatsuya, Takabe, Keiji, Shimizu, Takahiko, Irie, Kazuhiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2020
Konular:
Neurobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7152766/
https://ncbi.nlm.nih.gov/pubmed/32127399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010955
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