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Ex Vivo Rat Transected Spinal Cord Slices as a Model to Assess Lentiviral Vector Delivery of Neurotrophin-3 and Short Hairpin RNA against NG2

The failure of the spinal cord to regenerate can be attributed both to a lack of trophic support for regenerating axons and to upregulation of inhibitory factors such as chondroitin sulphate proteoglycans including NG2 following injury. Lentiviral vector-mediated gene therapy is a possible strategy...

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Detalhes bibliográficos
Publicado no:Biology (Basel)
Main Authors: Patar, Azim, Dockery, Peter, McMahon, Siobhan, Howard, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150802/
https://ncbi.nlm.nih.gov/pubmed/32183469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology9030054
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