Plant-based production of highly potent anti-HIV antibodies with engineered posttranslational modifications

Broadly neutralising antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1), such as CAP256-VRC26 are being developed for HIV prevention and treatment. These Abs carry a unique but crucial post-translational modification (PTM), namely O-sulfated tyrosine in the heavy chain complement...

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Pubblicato in:Sci Rep
Autori principali: Singh, Advaita Acarya, Pooe, Ofentse, Kwezi, Lusisizwe, Lotter-Stark, Therese, Stoychev, Stoyan H., Alexandra, Kabamba, Gerber, Isak, Bhiman, Jinal N., Vorster, Juan, Pauly, Michael, Zeitlin, Larry, Whaley, Kevin, Mach, Lukas, Steinkellner, Herta, Morris, Lynn, Tsekoa, Tsepo Lebiletsa, Chikwamba, Rachel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7148297/
https://ncbi.nlm.nih.gov/pubmed/32277089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63052-1
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