Intracellular Accumulation of Staphylopine Can Sensitize Staphylococcus aureus to Host-Imposed Zinc Starvation by Chelation-Independent Toxicity

The host restricts the availability of zinc to prevent infection. To overcome this defense, Staphylococcus aureus and Pseudomonas aeruginosa rely on zincophore-dependent zinc importers. Synthesis of the zincophore staphylopine by S. aureus and its import are both necessary for the bacterium to cause...

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Detalles Bibliográficos
Publicado en:J Bacteriol
Main Authors: Grim, Kyle P., Radin, Jana N., Solórzano, Paola K. Párraga, Morey, Jacqueline R., Frye, Katie A., Ganio, Katherine, Neville, Stephanie L., McDevitt, Christopher A., Kehl-Fie, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7148132/
https://ncbi.nlm.nih.gov/pubmed/32071094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00014-20
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