STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina

Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that this process can be induced in mouse MG, after injury, by transgenic expression of the proneural transcription factor Ascl1 and the HDAC inhibitor TSA. However, new neurons are generated only from a...

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Опубликовано в: :Cell Rep
Главные авторы: Jorstad, Nikolas L., Wilken, Matthew S., Todd, Levi, Finkbeiner, Connor, Nakamura, Paul, Radulovich, Nicholas, Hooper, Marcus J., Chitsazan, Alex, Wilkerson, Brent A., Rieke, Fred, Reh, Thomas A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7148114/
https://ncbi.nlm.nih.gov/pubmed/32075759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.075
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