ASCL1 reprograms mouse Müller glia into neurogenic retinal progenitors

Non-mammalian vertebrates have a robust ability to regenerate injured retinal neurons from Müller glia (MG) that activate the gene encoding the proneural factor Achaete-scute homolog 1 (Ascl1; also known as Mash1 in mammals) and de-differentiate into progenitor cells. By contrast, mammalian MG have...

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Autors principals: Pollak, Julia, Wilken, Matthew S., Ueki, Yumi, Cox, Kristen E., Sullivan, Jane M., Taylor, Russell J., Levine, Edward M., Reh, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2013
Matèries:
Stem Cells and Regeneration
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666387/
https://ncbi.nlm.nih.gov/pubmed/23637330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.091355
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