Histone deacetylases 1 and 2 silence cryptic transcription to promote mitochondrial function during cardiogenesis

Cryptic transcription occurs widely across the eukaryotic genome; however, its regulation during vertebrate development is not understood. Here, we show that two class I histone deacetylases, Hdac1 and Hdac2, silence cryptic transcription to promote mitochondrial function in developing murine hearts...

Full description

Saved in:
Bibliographic Details
Published in:Sci Adv
Main Authors: Milstone, Zachary J., Saheera, Sherin, Bourke, Lauren M., Shpilka, Tomer, Haynes, Cole M., Trivedi, Chinmay M.
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2020
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7148095/
https://ncbi.nlm.nih.gov/pubmed/32300642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax5150
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items