Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes

Extracellular vesicles (EVs) in the tumor microenvironment facilitate intercellular communication. Cancer cell-derived EVs act as an immunosuppressor by transporting cargos and presenting transmembrane proteins. By contrast, CD8+ cytotoxic T-lymphocytes (CTLs) exert anti-cancer cytotoxicity via the...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Tadokoro, Hiroko, Hirayama, Akiyoshi, Kudo, Ryuhei, Hasebe, Masako, Yoshioka, Yusuke, Matsuzaki, Juntaro, Yamamoto, Yusuke, Sugimoto, Masahiro, Soga, Tomoyoshi, Ochiya, Takahiro
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147783/
https://ncbi.nlm.nih.gov/pubmed/32275689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231430
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