Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes

Extracellular vesicles (EVs) in the tumor microenvironment facilitate intercellular communication. Cancer cell-derived EVs act as an immunosuppressor by transporting cargos and presenting transmembrane proteins. By contrast, CD8+ cytotoxic T-lymphocytes (CTLs) exert anti-cancer cytotoxicity via the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tadokoro, Hiroko, Hirayama, Akiyoshi, Kudo, Ryuhei, Hasebe, Masako, Yoshioka, Yusuke, Matsuzaki, Juntaro, Yamamoto, Yusuke, Sugimoto, Masahiro, Soga, Tomoyoshi, Ochiya, Takahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147783/
https://ncbi.nlm.nih.gov/pubmed/32275689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231430
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