α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity

Incorrect kinetochore–microtubule attachments during mitosis can lead to chromosomal instability, a hallmark of human cancers. Mitotic error correction relies on the kinesin-13 MCAK, a microtubule depolymerase whose activity in vitro is suppressed by α-tubulin detyrosination—a posttranslational modi...

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Xehetasun bibliografikoak
Argitaratua izan da:J Cell Biol
Egile Nagusiak: Ferreira, Luísa T., Orr, Bernardo, Rajendraprasad, Girish, Pereira, António J., Lemos, Carolina, Lima, Joana T., Guasch Boldú, Clàudia, Ferreira, Jorge G., Barisic, Marin, Maiato, Helder
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147099/
https://ncbi.nlm.nih.gov/pubmed/32328631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201910064
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