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α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity
Incorrect kinetochore–microtubule attachments during mitosis can lead to chromosomal instability, a hallmark of human cancers. Mitotic error correction relies on the kinesin-13 MCAK, a microtubule depolymerase whose activity in vitro is suppressed by α-tubulin detyrosination—a posttranslational modi...
में बचाया:
| में प्रकाशित: | J Cell Biol |
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| मुख्य लेखकों: | , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Rockefeller University Press
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7147099/ https://ncbi.nlm.nih.gov/pubmed/32328631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201910064 |
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