A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids

[Image: see text] The dinuclear photo-oxidizing Ru(II) complex [{Ru(TAP(2))}(2)(tpphz)](4+) (TAP = 1,4,5,8- tetraazaphenanthrene, tpphz = tetrapyrido[3,2-a:2′,3′-c:3″,2′′-h:2‴,3′′′-j]phenazine), 1(4+), is readily taken up by live cells localizing in mitochondria and nuclei. In this study, the two-ph...

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Udgivet i:J Am Chem Soc
Main Authors: Raza, Ahtasham, Archer, Stuart A., Fairbanks, Simon D., Smitten, Kirsty L., Botchway, Stanley W., Thomas, James A., MacNeil, Sheila, Haycock, John W.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146853/
https://ncbi.nlm.nih.gov/pubmed/32065521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b11313
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