Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation

BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer disease risk factor. Here, we investigate BIN1 function in the brain using conditional knockout (cKO) models. Loss of neuronal Bin1 expression results in the select impairment of spatial learning and memory. Exam...

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Publicat a:Cell Rep
Autors principals: De Rossi, Pierre, Nomura, Toshihiro, Andrew, Robert J., Masse, Nicolas Y., Sampathkumar, Vandana, Musial, Timothy F., Sudwarts, Ari, Recupero, Aleksandra J., Le Metayer, Thomas, Hansen, Mitchell T., Shim, Ha-Na, Krause, Sofia V., Freedman, David J., Bindokas, Vytas P., Kasthuri, Narayanan, Nicholson, Daniel A., Contractor, Anis, Thinakaran, Gopal
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146643/
https://ncbi.nlm.nih.gov/pubmed/32160554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.026
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