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Ibudilast, a Phosphodiesterase-4 Inhibitor, Ameliorates Acute Respiratory Distress Syndrome in Neonatal Mice by Alleviating Inflammation and Apoptosis

BACKGROUND: Acute respiratory distress syndrome (ARDS) is a sudden and serious disease with increasing morbidity and mortality rates. Phosphodiesterase 4 (PDE4) is a novel target for inflammatory disease, and ibudilast (IBU), a PDE4 inhibitor, inhibits inflammatory response. Our study investigated t...

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Bibliografische gegevens
Gepubliceerd in:Med Sci Monit
Hoofdauteurs: Yang, Dongjie, Yang, Yihan, Zhao, Yue
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: International Scientific Literature, Inc. 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146065/
https://ncbi.nlm.nih.gov/pubmed/32231178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.922281
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