Depot Medroxyprogesterone Acetate and the Vaginal Microbiome as Modifiers of Tenofovir Diphosphate and Lamivudine Triphosphate Concentrations in the Female Genital Tract of Ugandan Women: Implications for Tenofovir Disoproxil Fumarate/Lamivudine in Preexposure Prophylaxis

BACKGROUND: Effective concentrations of antiretrovirals in the female genital tract (FGT) are critical for suppression of viral shedding or effective preexposure prophylaxis. The disposition of tenofovir diphosphate (TFV-DP) and emtricitabine triphosphate (FTC-TP) in the FGT have been previously des...

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Vydáno v:Clin Infect Dis
Hlavní autoři: Nicol, Melanie R, Eneh, Prosperity, Nakalega, Rita, Kaiser, Thomas, Kabwigu, Samuel, Isingel, Esther, Beksinska, Mags, Sykes, Craig, Fowler, Mary Glenn, Brown, Todd T, Staley, Christopher, Kiweewa Matovu, Flavia
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146007/
https://ncbi.nlm.nih.gov/pubmed/31131846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciz443
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