Comparative lipidomics of 5-Fluorouracil–sensitive and –resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)

5-Fluorouracil (5-FU) is a chemotherapeutic drug widely used to treat colorectal cancer. 5-FU is known to gradually lose its efficacy in treating colorectal cancer following the acquisition of resistance. We investigated the mechanism of 5-FU resistance using comprehensive lipidomic approaches. We p...

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Publicado en:Sci Rep
Main Authors: Jung, Jae Hun, Taniguchi, Kohei, Lee, Hyeong Min, Lee, Min Young, Bandu, Raju, Komura, Kazumasa, Lee, Kil Yeon, Akao, Yukihiro, Kim, Kwang Pyo
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145850/
https://ncbi.nlm.nih.gov/pubmed/32273521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62823-0
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