Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition

BMVC is the first fluorescent probe designed to detect G-quadruplexes (G4s) in vivo. The MYC oncogene promoter forms a G4 (MycG4) which acts as a transcription silencer. Here, we report the high-affinity and specific binding of BMVC to MycG4 with unusual slow-exchange rates on the NMR timescale. We...

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Udgivet i:Nucleic Acids Res
Main Authors: Liu, Wenting, Lin, Clement, Wu, Guanhui, Dai, Jixun, Chang, Ta-Chau, Yang, Danzhou
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145684/
https://ncbi.nlm.nih.gov/pubmed/31740959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1015
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