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Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing intracellular enzyme that catalyzes the first and rate-determining step of tryptophan metabolism and is an important immunotherapeutic target for the treatment of cancer. In this study, we designed and synthesized a new series of compounds as...

詳細記述

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書誌詳細
出版年:Molecules
主要な著者: Zhou, Chuan, Lai, Fangfang, Sheng, Li, Chen, Xiaoguang, Li, Yan, Feng, Zhiqiang
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144934/
https://ncbi.nlm.nih.gov/pubmed/32210078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25061447
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