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Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing intracellular enzyme that catalyzes the first and rate-determining step of tryptophan metabolism and is an important immunotherapeutic target for the treatment of cancer. In this study, we designed and synthesized a new series of compounds as...

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Detaylı Bibliyografya
Yayımlandı:Molecules
Asıl Yazarlar: Zhou, Chuan, Lai, Fangfang, Sheng, Li, Chen, Xiaoguang, Li, Yan, Feng, Zhiqiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144934/
https://ncbi.nlm.nih.gov/pubmed/32210078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25061447
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