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Design, synthesis and biological evaluation of novel 2-phenyl pyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors

BTK is an effective target for the treatment of B-cell malignant tumors and autoimmune diseases. In this work, a series of 2-phenyl pyrimidine derivatives were prepared and their preliminary in vitro activities on B-cell leukemia cells as well as the BTK enzyme were determined. The results showed th...

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Detalles Bibliográficos
Publicado en:Medchemcomm
Main Authors: Li, Xinyu, Shi, Binyu, Teng, Yu, Cheng, Yu, Yang, Huizhu, Li, Jiurong, Wang, Lianjian, He, Siying, You, Qidong, Xiang, Hua
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390688/
https://ncbi.nlm.nih.gov/pubmed/30881616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00413g
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