Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension

Progressive loss of retinal ganglion cells (RGCs) leads to irreversible visual deficits in glaucoma. Here, we found that the level of cyclic AMP and the activity and expression of its mediator Epac1 were increased in retinas of two mouse models of ocular hypertension. Genetic depletion of Epac1 sign...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Liu, Wei, Ha, Yonju, Xia, Fan, Zhu, Shuang, Li, Yi, Shi, Shuizhen, Mei, Fang C., Merkley, Kevin, Vizzeri, Gianmarco, Motamedi, Massoud, Cheng, Xiaodong, Liu, Hua, Zhang, Wenbo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144517/
https://ncbi.nlm.nih.gov/pubmed/31918438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190930
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