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Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension
Progressive loss of retinal ganglion cells (RGCs) leads to irreversible visual deficits in glaucoma. Here, we found that the level of cyclic AMP and the activity and expression of its mediator Epac1 were increased in retinas of two mouse models of ocular hypertension. Genetic depletion of Epac1 sign...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7144517/ https://ncbi.nlm.nih.gov/pubmed/31918438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190930 |
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