Trehalose alleviates the phenotype of Machado–Joseph disease mouse models

BACKGROUND: Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is no treatment available to block or delay disease progression...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Transl Med
Päätekijät: Santana, Magda M., Paixão, Susana, Cunha-Santos, Janete, Silva, Teresa Pereira, Trevino-Garcia, Allyson, Gaspar, Laetitia S., Nóbrega, Clévio, Nobre, Rui Jorge, Cavadas, Cláudia, Greif, Hagar, Pereira de Almeida, Luís
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2020
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144062/
https://ncbi.nlm.nih.gov/pubmed/32272938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02302-2
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