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Trehalose alleviates the phenotype of Machado–Joseph disease mouse models
BACKGROUND: Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is no treatment available to block or delay disease progression...
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| Publicado no: | J Transl Med |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7144062/ https://ncbi.nlm.nih.gov/pubmed/32272938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02302-2 |
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