Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

Machado–Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a polyglutamine tract within the ataxin-3 protein. The available treatments only ameliorate symptomatology and do not block disease progression....

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Bibliographic Details
Published in:Nat Commun
Main Authors: Cunha-Santos, Janete, Duarte-Neves, Joana, Carmona, Vitor, Guarente, Leonard, Pereira de Almeida, Luís, Cavadas, Cláudia
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865854/
https://ncbi.nlm.nih.gov/pubmed/27165717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11445
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