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Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring

[Image: see text] We have developed a rapid and sensitive single-well dual-parametric method introduced in linked RAS nucleotide exchange and RAS/RAF-RBD interaction assays. RAS mutations are frequent drivers of multiple different human cancers, but the development of therapeutic strategies has been...

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Bibliografske podrobnosti
izdano v:Anal Chem
Main Authors: Kopra, Kari, Vuorinen, Emmiliisa, Abreu-Blanco, Maria, Wang, Qi, Eskonen, Ville, Gillette, William, Pulliainen, Arto T., Holderfield, Matthew, Härmä, Harri
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2020
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7143314/
https://ncbi.nlm.nih.gov/pubmed/32106676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b05126
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