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Influence of Dominance and Drift on Lethal Mutations in Human Populations
We consider disease-causing mutations that are lethal when homozygous. Lethality involves the very strongest form of negative selection, with the selection coefficient against the disease-carrying homozygote having its maximum value of unity. We determine results for the behavior of the frequency of...
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| Publicado no: | Front Genet |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7142268/ https://ncbi.nlm.nih.gov/pubmed/32300356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00267 |
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