Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling

Fear memory extinction (FE) is an important therapeutic goal for Posttraumatic stress disorder (PTSD). Cotinine facilitates FE in rodents, in part due to its inhibitory effect on the amygdala by the glutamatergic projections from the medial prefrontal cortex (mPFC). The cellular and behavioral effec...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Oliveros-Matus, Patricia, Perez-Urrutia, Nelson, Alvarez-Ricartes, Nathalie, Echeverria, Florencia, Barreto, George E., Elliott, James, Iarkov, Alexandre, Echeverria, Valentina
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142247/
https://ncbi.nlm.nih.gov/pubmed/32300297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00303
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