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Chemical Synthesis and Immunological Evaluation of Pertussis-Like Pentasaccharide Bearing Multiple Rare Sugars as a Potential Anti-pertussis Vaccine

The 60-year high Bordetella pertussis (B. pertussis) infection rate in the world suggests the urgent need for new anti-pertussis vaccines. Lipopolysaccharide (LPS) of B. pertussis is an attractive antigen for vaccine development. With the presence of multiple rare sugars and unusual glycosyl linkage...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Wang, Peng, Huo, Chang-xin, Lang, Shuyao, Caution, Kyle, Nick, Setare Tahmasebi, Dubey, Purnima, Deora, Rajendar, Huang, Xuefei
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141973/
https://ncbi.nlm.nih.gov/pubmed/31953912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201915913
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