Endogenous Apelin Is Protective Against Age-Associated Loss of Retinal Ganglion Cells in Mice

Age-associated loss of retinal ganglion cells (RGCs) causes visual deficits, but there is not yet any therapeutic agent to prevent the loss of these cells. Herein, we report that apelin, an endogenous peptide ligand of APJ receptor, is protective against the age-related loss of RGCs in mice. The mRN...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Ishimaru, Yuki, Sumino, Akihide, Shibagaki, Fumiya, Yamamuro, Akiko, Yoshioka, Yasuhiro, Maeda, Sadaaki
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141441/
https://ncbi.nlm.nih.gov/pubmed/32296325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00058
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