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Endogenous Apelin Is Protective Against Age-Associated Loss of Retinal Ganglion Cells in Mice

Age-associated loss of retinal ganglion cells (RGCs) causes visual deficits, but there is not yet any therapeutic agent to prevent the loss of these cells. Herein, we report that apelin, an endogenous peptide ligand of APJ receptor, is protective against the age-related loss of RGCs in mice. The mRN...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Aging Neurosci
Prif Awduron: Ishimaru, Yuki, Sumino, Akihide, Shibagaki, Fumiya, Yamamuro, Akiko, Yoshioka, Yasuhiro, Maeda, Sadaaki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141441/
https://ncbi.nlm.nih.gov/pubmed/32296325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00058
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