Serine/threonine phosphatase PP2A is essential for optimal B cell function

Protein phosphatase 2A (PP2A), a serine/threonine phosphatase, has been shown to control T cell function. We found that in vitro–activated B cells and B cells from various lupus-prone mice and patients with systemic lupus erythematosus display increased PP2A activity. To understand the contribution...

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Pubblicato in:JCI Insight
Autori principali: Meidan, Esra, Li, Hao, Pan, Wenliang, Kono, Michihito, Yu, Shuilian, Kyttaris, Vasileios C., Ioannidis, Christina, Rodriguez Rodriguez, Noe, Crispin, Jose C., Apostolidis, Sokratis A., Lee, Pui, Manis, John, Sharabi, Amir, Tsokos, Maria G., Tsokos, George C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141385/
https://ncbi.nlm.nih.gov/pubmed/32161189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130655
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