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Kinetic Basis of Carbohydrate-Mediated Inhibition of Human Glucokinase by the Glucokinase Regulatory Protein

The glucokinase regulatory protein (GKRP) is a competitive inhibitor of glucokinase (GCK), triggering its localization to the hepatocyte nucleus upon glucose deprivation. Here we establish the kinetic mechanism of GKRP action by analyzing its association with a genetically encoded, fluorescent varia...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Casey, Ashley K., Miller, Brian G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140980/
https://ncbi.nlm.nih.gov/pubmed/27174229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00349
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