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Does DNA Methylation Matter in FSHD?

Facioscapulohumeral muscular dystrophy (FSHD) has been associated with the genetic and epigenetic molecular features of the CpG-rich D4Z4 repeat tandem array at 4q35. Reduced DNA methylation of D4Z4 repeats is considered part of the FSHD mechanism and has been proposed as a reliable marker in the FS...

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Vydáno v:Genes (Basel)
Hlavní autoři: Salsi, Valentina, Magdinier, Frédérique, Tupler, Rossella
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140823/
https://ncbi.nlm.nih.gov/pubmed/32121044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11030258
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