Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration

Patients with certain defects in the dehydrodolichyl diphosphate synthase (DHDDS) gene (RP59; OMIM #613861) exhibit classic symptoms of retinitis pigmentosa, as well as macular changes, suggestive of retinal pigment epithelium (RPE) involvement. The DHDDS enzyme is ubiquitously required for several...

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Pubblicato in:Cells
Autori principali: DeRamus, Marci L., Davis, Stephanie J., Rao, Sriganesh Ramachandra, Nyankerh, Cyril, Stacks, Delores, Kraft, Timothy W., Fliesler, Steven J., Pittler, Steven J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140717/
https://ncbi.nlm.nih.gov/pubmed/32245241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9030771
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