Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling

Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson’s disease (PD); howev...

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Veröffentlicht in:Cells
Hauptverfasser: Hong, Chien-Tai, Chen, Kai-Yun, Wang, Weu, Chiu, Jing-Yuan, Wu, Dean, Chao, Tsu-Yi, Hu, Chaur-Jong, Chau, Kai-Yin David, Bamodu, Oluwaseun Adebayo
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140619/
https://ncbi.nlm.nih.gov/pubmed/32192190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9030740
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