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Predicting liver cytosol stability of small molecules
Over the last few decades, chemists have become skilled at designing compounds that avoid cytochrome P (CYP) 450 mediated metabolism. Typical screening assays are performed in liver microsomal fractions and it is possible to overlook the contribution of cytosolic enzymes until much later in the drug...
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| Veröffentlicht in: | J Cheminform |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer International Publishing
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7140498/ https://ncbi.nlm.nih.gov/pubmed/33431020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-020-00426-7 |
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