Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety

Monomethyl auristatin E (MMAE) is the most popular and widely used cytotoxin in the development of antibody-drug conjugates (ADCs). However, current MMAE-based ADCs are all constructed using cleavable linkers, and this design concept still has insurmountable drawbacks. Their potential instabilities...

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Bibliografiska uppgifter
I publikationen:Cancers (Basel)
Huvudupphovsmän: Wang, Yanming, Liu, Lianqi, Fan, Shiyong, Xiao, Dian, Xie, Fei, Li, Wei, Zhong, Wu, Zhou, Xinbo
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140114/
https://ncbi.nlm.nih.gov/pubmed/32245171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030744
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