The NANOG Transcription Factor Induces Type 2 Deiodinase Expression and Regulates the Intracellular Activation of Thyroid Hormone in Keratinocyte Carcinomas

Type 2 deiodinase (D2), the principal activator of thyroid hormone (TH) signaling in target tissues, is expressed in cutaneous squamous cell carcinomas (SCCs) during late tumorigenesis, and its repression attenuates the invasiveness and metastatic spread of SCC. Although D2 plays multiple roles in c...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Nappi, Annarita, Di Cicco, Emery, Miro, Caterina, Cicatiello, Annunziata Gaetana, Sagliocchi, Serena, Mancino, Giuseppina, Ambrosio, Raffaele, Luongo, Cristina, Di Girolamo, Daniela, De Stefano, Maria Angela, Porcelli, Tommaso, Stornaiuolo, Mariano, Dentice, Monica
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140064/
https://ncbi.nlm.nih.gov/pubmed/32197405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030715
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