Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma

PURPOSE: Targeting tumor blood vessels is an attractive therapy in glioblastoma (GBM), but the mechanism of action of these agents and how they modulate delivery of concomitant chemotherapy are not clear in humans. We sought to elucidate how bevacizumab modulates tumor vasculature and the impact tho...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Gerstner, Elizabeth R., Emblem, Kyrre E., Chang, Ken, Vakulenko-Lagun, Bella, Yen, Yi-Fen, Beers, Andrew L., Dietrich, Jorg, Plotkin, Scott R., Catana, Ciprian, Hooker, Jacob M., Duda, Dan G., Rosen, Bruce, Kalpathy-Cramer, Jayashree, Jain, Rakesh K., Batchelor, Tracy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139851/
https://ncbi.nlm.nih.gov/pubmed/31558474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1739
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