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Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma

PURPOSE: Targeting tumor blood vessels is an attractive therapy in glioblastoma (GBM), but the mechanism of action of these agents and how they modulate delivery of concomitant chemotherapy are not clear in humans. We sought to elucidate how bevacizumab modulates tumor vasculature and the impact tho...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Gerstner, Elizabeth R., Emblem, Kyrre E., Chang, Ken, Vakulenko-Lagun, Bella, Yen, Yi-Fen, Beers, Andrew L., Dietrich, Jorg, Plotkin, Scott R., Catana, Ciprian, Hooker, Jacob M., Duda, Dan G., Rosen, Bruce, Kalpathy-Cramer, Jayashree, Jain, Rakesh K., Batchelor, Tracy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139851/
https://ncbi.nlm.nih.gov/pubmed/31558474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1739
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