Sustained Release of Decoy Wnt Receptor (sLRP6E1E2)-Expressing Adenovirus Using Gel-Encapsulation for Scar Remodeling in Pig Model

An adenoviral vector (Ad) expressing a Wnt decoy receptor (sLRP6E1E2) is known to induce an anti-fibrotic effect by inhibiting Wnt signaling. We evaluated its effects in vivo using pig models and attempted to introduce an alginate gel-matrix system to prolong the effect of the Ad. Transduction effic...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Yang, Chae-Eun, Choi, Sewoon, Lee, Ju Hee, Kang, Eun Hye, Ahn, Hyo Min, Roh, Tai Suk, Yun, Chae-Ok, Lee, Won Jai
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139745/
https://ncbi.nlm.nih.gov/pubmed/32213906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21062242
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